Questions and Answers Restylane

Restylane® is a range of products for facial beauty treatment. They are designed to
effectively reduce the appearance of unwanted wrinkles, contour and create volume,
and to rejuvenate the skin. Restylane is a gel based on stabilized hyaluronic acid.
Hyaluronic acid (HA) is a substance that naturally exists in your body. The gel is
injected into the skin.

A treatment with Restylane provides an easy way to stay in control of your looks. The
result of a single treatment can be seen instantly and may last up to one year. With
Restylane you will get a natural looking result that does not affect facial expressions.
Your looks remain under your control.

Restylane is the most studied and documented HA based dermal filler in the world
with comprehensive studies that support its safety and efficacy. Restylane has been
used in over 10 million treatments worldwide during the last twelve years.

• It is safe. Restylane resembles the body’s own hyaluronic acid, and is well tested in
  clinical studies.
• It works. Restylane has long-lasting results, but is not permanent. It is clinically
  proven with extensive clinical documentation.
• It is the most used. Restylane has been used in over 10 million treatments worldwide
  during the last twelve years.

Restylane products can be used to smooth away facial lines and wrinkles, create
fuller lips and shape facial contours, such as cheeks and chin, and rejuvenate the
skin.

The most common areas treated are:

• nose to mouth lines (the nasolabial folds)
• between the eyebrows (the glabella lines)
• lips (adding volume and shape)
• cheeks and chin (shaping and contouring)
• back of the hands, décolletage, face, neck (skin rejuvenation)
  Link to indication picture

By replenishing the skin’s supply of hyaluronic acid, Restylane rejuvenates and adds
volume to the skin, instantly diminishing the appearance of lines and wrinkles, and
giving a natural softer look. Restylane is a soft injectable gel consisting of stabilized,
non-animal hyaluronic acid. The gel is tissue-friendly and closely resembles the
hyaluronic acid that exists naturally in the body. It is long-lasting but not permanent.

Before
Start by making an appointment with a qualified practicioner. During consultation be
prepared to discuss your individual wishes and expectations and receive
recommendations of which Restylane treatment is most suitable for you. This will be
based on what you wish to achieve, your features and individual life style factors.
After the consultation you will receive the appropriate treatment.

During
Restylane is injected into the skin in small amounts using a very fine needle. The gel
provides natural volume to smooth away the appearance of lines and wrinkles,
enhance facial shape, or create fuller lips. Restylane Vital products improve the
elasticity and texture of skin, and restores and maintain the skin hydrobalance..

The treatment is quick, typically taking about 30 minutes. Treatment with Restylane
does not affect facial expression and the benefits can normally be seen instantly.

After
Restylane products are biodegradable, which means they will naturally disappear in
the body. A follow-up treatment is usually needed after 6 to 12 months depending on
individual factors and area treated. Discuss with your practicioner when a follow-up
might be needed.

After a treatment some reactions might occur. Most common is slight redness,
swelling, itching, bruising, pain and tenderness. The reactions are generally mild to
moderate and usually disappear shortly after injection. They usually resolve
spontaneously within one or two days after injection, but for some treatments they
may last longer.

First of all you should always contact a qualified practicioner to be assured that the
treatment will be performed correctly. For your safety, be prepared to discuss your
medical history during your pre-treatment consultation.

One of the great advantages of Restylane is that the effects are long lasting but not
permanent. Duration depends on many factors, such as the individual’s skin type,
lifestyle and age. After the initial treatment, follow-up sessions are normally
recommended around every 6 to 12 months depending on the individual and the
treatment. A treatment of the lips lasts about 6 months.

Most people can benefit from Restylane treatment. If you want to reduce lines and
wrinkles or create more defined or fuller lips, Restylane can help. Also if you want to
define the contours of your face, such as chin or cheek, or rejuvenate the skin in your
face, on your hands, neck or décolletage, Restylane is a good option for you.

Restylane should not be used in or near areas where there is or has been skin
disease, inflammation or related conditions. Restylane has not been tested in
pregnant or breast-feeding women. Individuals with medical conditions that lower the
body’s immune response or individuals undergoing therapy that is
immunosuppressive may be more prone to infection by a skin injection procedure.

During your pre-treatment consultation, you should thoroughly discuss your medical
history with your practicioner.

Generally, pain relief is not necessary when injecting into the skin to correct wrinkles.
Some people may experience the treatment as a mild discomfort. A local anaesthetic
cream can be applied to the area to avoid pain.

The lips are a highly sensitive part of the body and, therefore, anaesthesia is usually
recommended before lip enhancement. This is achieved most effectively by using a
dental block or local anaesthetic.

Restylane and Restylane Perlane are now also available with the local anaesthetiv lidocaine included for a more comfortable treatment experience.

More than 10 million treatments have been performed since the launch of Restylane
in 1996. Product related reactions are rare. There are some injection related
reactions which may occur after any injection; they typically resolve spontaneously a
few days after injection to the skin, within a week after injection into the lips and
within two weeks after injection with Restylane SubQ. These reactions include
redness, swelling, pain, itching, bruising or tenderness at the injection site.

After a lip enhancement, your lips may be swollen for up to a week.

In case of more pronounced reactions or if they last longer than a week contact your
practicioner.

As with all skin injection procedures there is a small risk of infection. Local
inflammatory reactions described as mild to moderate and usually self-limiting within
2 weeks have rarely been reported.

For full adverse event information please discuss with your practicioner.

Restylane is the world’s most tried and tested HA dermal filler available today. It is
the benchmark for clinical excellence in its field. Its safety and effect are clinically
proven and supported by extensive clinical data. Restylane has been used for 12
years and in more than 10 million treatments world wide. Research and development
is continuous.

Restylane consists of a range of different products tailored for your individual needs. Discuss
with your practicioner during your pre-treatment consultation what products suits your needs
best.

Restylane is developed and produced by the Swedish biotechnology company QMed
AB, with headquarters in Uppsala, Sweden, and offices all around the world. QMed
has continuous research and development programs where safety and quality
are top priorities. Restylane has today been proven to be safe, effective and long
lasting, which is supported with the experience of more than a decade of clinical use
and over 10 million treatments worldwide.

No skin test is required; Restylane does not contain any animal-derived ingredients.

If you have recently had a laser or chemical peel treatment, it is recommended you
wait until the area is totally healed and the skin is back to its normal condition.
Consult your practicioner.

Q-Med has patented a unique technology, NASHA™, which stabilizes hyaluronic acid
to make it long lasting, yet similar to the body’s own hyaluronic acid.